Overactive bladder syndrome, neurogenic detrusor overactivity

Active Ingredient: Propiverine

Indication for Propiverine

Population group: only adults (18 years old or older)

Symptomatic treatment of urinary incontinence and/or increased urinary frequency and urgency in patients with overactive bladder syndrome or neurogenic detrusor overactivity from spinal cord injuries.

For this indication, competent medicine agencies globally authorize below treatments:

15-45 mg in 1-3 divided doses daily

Route of admnistration


Defined daily dose

15 - 45 mg

Dosage regimen

From 5 To 15 mg 3 time(s) per day every day

Detailed description

As a standard dose 15 mg propiverine hydrochloride twice daily is recommended, this may be increased to three times daily. Some patients may already respond to a dose of 15 mg daily.

For neurogenic detrusor overactivity a dose of 15 mg three times daily is recommended. The maximum recommended daily dose is 45 mg.

Dosage considerations

A high fat meal increases the bioavailability of propiverine. Therefore, propiverine should be taken before meals; especially in patients with renal or hepatic impairment.

Active ingredient


Propiverine inhibits calcium influx and modulates intracellular calcium in urinary bladder smooth muscle cells causing musculotropic spasmolysis. Also, it inhibits the efferent connection of the nervus pelvicus due to anticholinergic action.

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