Malignant neoplastic disease

Active Ingredient: Ifosfamide

Indication for Ifosfamide

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Ifosfamide is a cytotoxic drug for the treatment of malignant disease. As a single agent it has successfully produced objective remissions in a wide range of malignant conditions. Ifosfamide is also frequently used in combination with other cytotoxic drugs, radiotherapy and surgery.

For this indication, competent medicine agencies globally authorize below treatments:

5-9 g/m² once a day

Route of admnistration


Defined daily dose

5 - 9 g per m² of body surface area (BSA)

Dosage regimen

From 5 To 9 g per m² of body surface area (BSA) once every day

Detailed description

In children, the dosage and administration should be determined by the tumour type, tumour stage, the general condition of the patient, any previous cytotoxic therapy, and whether chemotherapy or radiotherapy is to be administered concurrently. Clinical trials have involved doses of:

  • 5 g/m² over 24 hours
  • 9 g/m² equally fractionated as single daily doses over 5 days
  • 9 g/m² as a continuous infusion over 72 hours repeated at three weekly intervals.

Active ingredient


Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.

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