Ifosfamide

Chemical formula: C₇H₁₅Cl₂N₂O₂P  Molecular mass: 261.086 g/mol  PubChem compound: 3690

Active ingredient description

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01AA06 Ifosfamide L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues
Discover more medicines within L01AA06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
IFEX Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR
IFOSFAMIDE INJECTION Powder for concentrate for solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 3778-73-2
DrugBank Drug: DB01181
KEGG Drug: D00343
PubChem Compound: 3690
RxNorm Ingredient: 5657
SNOMED-CT Concept: 386904003
Ifosfamide (substance)
UNII Identifier: UM20QQM95Y
IFOSFAMIDE

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