Active Ingredient: Vitamin B12a
Treatment of known or suspected cyanide poisoning in all age ranges.
Hydroxocobalamin is to be administered together with appropriate decontamination and supportive measures.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 5 grams vitamin B12a, 1 to 2 doses in total.
The initial dose of hydroxocobalamin is 5 g.
Depending upon the severity of the poisoning and the clinical response, a second dose may be administered.
The subsequent dose of hydroxocobalamin is 5 g.
The maximum total recommended dose is 10 g.
Initial dose of hydroxocobalamin is administered as an intravenous infusion over 15 minutes.
The rate of intravenous infusion for the second dose ranges from 15 minutes (for patients extremely unstable) to 2 hours based on patient condition.
For:
Intravenous, 70 milligrams vitamin B12a per kilogram of body weight, 1 to 2 doses in total.
In infants to adolescents (0 to 18 years old), the initial dose of hydroxocobalamin is 70 mg/kg body weight not exceeding 5 g.
Depending upon the severity of the poisoning and the clinical response, a second dose may be administered.
In infants to adolescents (0 to 18 years old), the subsequent dose of hydroxocobalamin is 70 mg/kg body weight not exceeding 5 g.
| Body weight in kg | 5 | 10 | 20 | 30 | 40 | 50 | 60 |
| Initial dose in g | 0.35 | 0.70 | 1.40 | 2.10 | 2.80 | 3.50 | 4.20 |
In infants to adolescents (0 to 18 years old), the maximum total recommended dose is 140 mg/kg not exceeding 10 g.
Initial dose of hydroxocobalamin is administered as an intravenous infusion over 15 minutes.
The rate of intravenous infusion for the second dose ranges from 15 minutes (for patients extremely unstable) to 2 hours based on patient condition.
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