Active Ingredient: Aprepitant
Prevention nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in adults.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
80 - 125 mg
From 80 To 125 mg once every day
125 mg
80 mg
Aprepitant is given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonist. The recommended dose is 125 mg orally once daily one hour before start of chemotherapy on Day 1 and 80 mg orally once daily on Days 2 and 3 in the morning
The following regimens are recommended in adults for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.
Highly Emetogenic Chemotherapy Regimen:
| Day 1 | Day 2 | Day 3 | Day 4 | |
|---|---|---|---|---|
| Aprepitant | 125 mg orally | 80 mg orally | 80 mg orally | none |
| Dexamethasone | 12 mg orally | 8 mg orally | 8 mg orally | 8 mg orally |
| 5-HT3 antagonists | Standard dose of 5-HT3 antagonists. See the product information for the selected 5-HT3 antagonist for ppropriate dosing nformation | none | none | none |
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 to 4. The dose of dexamethasone accounts for active substance interactions.
Moderately Emetogenic Chemotherapy Regimen:
| Day 1 | Day 2 | Day 3 | |
|---|---|---|---|
| Aprepitant | 125 mg orally | 80 mg orally | 80 mg orally |
| Dexamethasone | 12 mg orally | none | none |
| 5-HT3 antagonists | Standard dose of 5-HT3 antagonists. See the product information for the selected 5-HT3 antagonist for appropriate dosing information | none | none |
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for active substance interactions.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.