Prevention nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in adults.
For this indication, competent medicine agencies globally authorize below treatments:
80 - 125 mg
From 80 To 125 mg once every day
Aprepitant is given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonist. The recommended dose is 125 mg orally once daily one hour before start of chemotherapy on Day 1 and 80 mg orally once daily on Days 2 and 3 in the morning
The following regimens are recommended in adults for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.
Highly Emetogenic Chemotherapy Regimen:
|Day 1||Day 2||Day 3||Day 4|
|Aprepitant||125 mg orally||80 mg orally||80 mg orally||none|
|Dexamethasone||12 mg orally||8 mg orally||8 mg orally||8 mg orally|
|5-HT3 antagonists||Standard dose of 5-HT3 antagonists. See the product information for the selected 5-HT3 antagonist for ppropriate dosing nformation||none||none||none|
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 to 4. The dose of dexamethasone accounts for active substance interactions.
Moderately Emetogenic Chemotherapy Regimen:
|Day 1||Day 2||Day 3|
|Aprepitant||125 mg orally||80 mg orally||80 mg orally|
|Dexamethasone||12 mg orally||none||none|
|5-HT3 antagonists||Standard dose of 5-HT3 antagonists. See the product information for the selected 5-HT3 antagonist for appropriate dosing information||none||none|
Dexamethasone should be administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for active substance interactions.
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