Aprepitant

Active ingredient description

Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A04AD12
Aprepitant
A Alimentary tract and metabolism → A04 Antiemetics and antinauseants → A04A Antiemetics and antinauseants → A04AD Other antiemetics
Discover more medicines within A04AD12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
EMEND Hard capsule
Summary of Product Characteristics (SPC)

Medicines

Aprepitant is the active ingredient of these drugs:

Drug
Countries
ALFENIL

Ecuador

APREPILOR

Germany

ARENTA

South Africa

ATANTO

Austria

CINVANTI

United States

EMEND

Austria Brazil Canada Cyprus Ecuador

ENTAGER

South Africa

GOMESIS

South Africa

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₃H₂₁F₇N₄O₃
Molecular mass: 534.427 g/mol

External identifiers

CAS Substance: 170729-80-3
DrugBank Drug: DB00673
KEGG Drug: D02968
PubChem Compound: 135413536
RxNorm Ingredient: 358255
SNOMED-CT Concept: 409205009
Aprepitant (substance)
UNII Identifier: 1NF15YR6UY
APREPITANT
 
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