Aprepitant

Active ingredient description

Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Aprepitant
A Alimentary tract and metabolism → A04 Antiemetics and antinauseants → A04A Antiemetics and antinauseants → A04AD Other antiemetics
Discover more medicines within A04AD12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)

Medicines

Aprepitant is the active ingredient of these drugs:

Drug
Countries

Ecuador

Germany

South Africa

Austria

United States

Austria Brazil Canada Cyprus Ecuador

South Africa

South Africa

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₃H₂₁F₇N₄O₃
Molecular mass: 534.427 g/mol

External identifiers

CAS Substance: 170729-80-3
DrugBank Drug: DB00673
KEGG Drug: D02968
PubChem Compound: 135413536
RxNorm Ingredient: 358255
SNOMED-CT Concept: 409205009
Aprepitant (substance)
UNII Identifier: 1NF15YR6UY
APREPITANT