ATC Group: A04AD Other antiemetics

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of A04AD in the ATC hierarchy

Level
Code
Title
1
Alimentary tract and metabolism
2
Antiemetics and antinauseants
3
Antiemetics and antinauseants
4
A04AD
Other antiemetics

Group A04AD contents

Code
Title
Scopolamine
Cerium oxalate
Chlorobutanol
Metopimazine
Dronabinol
Nabilone
Aprepitant
Scopolamine, combinations
Chlorobutanol, combinations

Active ingredients in A04AD

Active Ingredient
Description

Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.

Dronabinol is an active ingredient of cannabis, which has complex effects on the CNS, including central sympathomimetic activity. Dronabinol exerts its action by activating CB1 and CB2 recepors which makes it a CNS active medicine.

Fosaprepitant is the prodrug of aprepitant and when administered intravenously is converted rapidly to aprepitant. The contribution of fosaprepitant to the overall antiemetic effect has not fully been characterised, but a transient contribution during the initial phase cannot be ruled out.

Nabilone is a synthetic cannabinoid and dibenzopyrane derivative, an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.

Rolapitant is a selective antagonist of human substance P/neurokinin 1 (NK1) receptors.

Scopolamine is a naturally occurring belladonna alkaloid and has anticholinergic properties. It acts as a competitive antagonist to acetylchloline and other parasympathomimetic agents. Its mechanism of action in the central nervous system in preventing motion sickness has yet to be elucidated. Scopolamine produces classical symptoms of parasympathetic blockade.

Related product monographs

Title
Type
Country
Structured Product Labeling (SPL)
US
Summary of Product Characteristics (SPC)
Structured Product Monograph (SPM)
CA
Summary of Product Characteristics (SPC)
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK