ATC Group: A04AD Other antiemetics

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of A04AD in the ATC hierarchy

Level Code Title
1 A Alimentary tract and metabolism
2 A04 Antiemetics and antinauseants
3 A04A Antiemetics and antinauseants
4 A04AD Other antiemetics

Group A04AD contents

Code Title
A04AD01 Scopolamine
A04AD02 Cerium oxalate
A04AD04 Chlorobutanol
A04AD05 Metopimazine
A04AD10 Dronabinol
A04AD11 Nabilone
A04AD12 Aprepitant
A04AD51 Scopolamine, combinations
A04AD54 Chlorobutanol, combinations

Active ingredients in A04AD

Active Ingredient Description

Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.


Dronabinol is an active ingredient of cannabis, which has complex effects on the CNS, including central sympathomimetic activity. Dronabinol exerts its action by activating CB1 and CB2 recepors which makes it a CNS active medicine.


Fosaprepitant is the prodrug of aprepitant and when administered intravenously is converted rapidly to aprepitant. The contribution of fosaprepitant to the overall antiemetic effect has not fully been characterised, but a transient contribution during the initial phase cannot be ruled out.


Nabilone is a synthetic cannabinoid and dibenzopyrane derivative, an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.


Rolapitant is a selective antagonist of human substance P/neurokinin 1 (NK1) receptors.


Scopolamine is a naturally occurring belladonna alkaloid and has anticholinergic properties. It acts as a competitive antagonist to acetylchloline and other parasympathomimetic agents. Its mechanism of action in the central nervous system in preventing motion sickness has yet to be elucidated. Scopolamine produces classical symptoms of parasympathetic blockade.

Related product monographs

Title Information Source Document Type  
CESAMET Capsule FDA, National Drug Code (US) MPI, US: SPL/Old
EMEND Hard capsule European Medicines Agency (EU) MPI, EU: SmPC
EMEND IV Fosaprepitant for injection Health Products and Food Branch (CA) MPI, CA: SPM
IVEMEND Powder for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC
KWELLS KIDS Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
SCOPODERM Transdermal patch Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC