Chemical formula: C₂₄H₃₆O₃ Molecular mass: 372.541 g/mol PubChem compound: 5284592
Nabilone is a synthetic cannabinoid and dibenzopyrane derivative, an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A04AD11 | Nabilone | A Alimentary tract and metabolism → A04 Antiemetics and antinauseants → A04A Antiemetics and antinauseants → A04AD Other antiemetics |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CESAMET Capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Nabilone is an active ingredient of these brands:
United States (US)Austria (AT)Canada (CA)Israel (IL)Mexico (MX)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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