Active Ingredient: Valproic acid
Treatment of generalised, partial or other epilepsy.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
600 - 2,500 mg
From 200 To 833.333 mg 3 time(s) per day every day
Dosage should start at 600 mg daily increasing by 200 mg at three-day intervals until control is achieved. This is generally within the dosage range 1,000–2,000 mg per day, i.e. 20–30 mg/kg/day body weight (to the nearest whole 50 mg sachet). Where adequate control is not achieved within this range the dose may be further increased to 2,500 mg per day.
Intravenous
10 - 25 mg per kg of body weight
From 10 To 25 mg per kg of body weight once every day
Valproate acid intravenous may be given by direct slow intravenous injection or by infusion using a separate intravenous line in normal saline, dextrose 5%, or dextrose saline.
Daily dosage requirements vary according to age and body weight.
To reconstitute, inject the solvent provided (4 ml) into the vial, allow to dissolve and extract the appropriate dose. Due to displacement of solvent by sodium valproate the concentration of reconstituted sodium valproate is 95 mg/ml.
Each vial of valproate acid intravenous is for single dose injection only. It should be reconstituted immediately prior to use and infusion solutions containing it used within 24 hours. Any unused portion should be discarded.
Valproate acid intravenous should not be administered via the same IV line as other IV additives. The intravenous solution is suitable for infusion by PVC, polyethylene or glass containers.
Patients already satisfactorily treated with valproate acid may be continued at their current dosage using continuous or repeated infusion. Other patients may be given a slow intravenous injection over 3–5 minutes, usually 400–800 mg depending on body weight (up to 10 mg/kg) followed by continuous or repeated infusion up to a maximum of 2,500 mg/day.
Valproate acid intravenous should be replaced by oral valproate acid therapy as soon as practicable.
Oral
10 - 60 mg per kg of body weight
From 3.333 To 20 mg per kg of body weight 3 time(s) per day every day
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