Major depressive disorder

Active Ingredient: Amitriptyline

Indication for Amitriptyline

Population group: only adults (18 - 65 years old)

Amitriptyline is indicated for the treatment of major depressive disorder in adults.

For this indication, competent medicine agencies globally authorize below treatments:

50-150 mg daily

Route of admnistration

Oral

Defined daily dose

50 - 150 mg

Dosage regimen

From 25 To 75 mg 2 time(s) per day every day for 180 day(s)

Detailed description

Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerability.

Initially 25 mg 2 times daily (50 mg daily). If necessary, the dose can be increased by 25 mg every other day up to 150 mg daily divided into two doses.
The maintenance dose is the lowest effective dose.

Duration of treatment

The antidepressant effect usually sets in after 2-4 weeks. Treatment with antidepressants is symptomatic and must therefore be continued for an appropriate length of time usually up to 6 months after recovery in order to prevent relapse.

Active ingredient

Amitriptyline

Amitriptyline is a tricyclic antidepressant and an analgesic. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity.

Read more about Amitriptyline

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