Active Ingredient: Pegvisomant
Treatment of adult patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalize IGF-I concentrations or was not tolerated.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
10 - 30 mg
From 10 To 30 mg once every day
80 mg
A loading dose of 80 mg pegvisomant should be administered subcutaneously under medical supervision. Following this, pegvisomant 10 mg reconstituted in 1 ml of solvent should be administered once daily as a subcutaneous injection.
Dose adjustments should be based on serum IGF-I levels. Serum IGF-I concentrations should be measured every four to six weeks and appropriate dose adjustments made in increments of 5 mg/day in order to maintain the serum IGF-I concentration within the age-adjusted normal range and to maintain an optimal therapeutic response.
The maximum dose should not exceed 30 mg/day.
The site of injection should be rotated daily to help prevent lipohypertrophy.
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