Essential hypertension

Active Ingredient: Captopril

Indication for Captopril

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Captopril is indicated for the treatment of essential hypertension.

For this indication, competent medicine agencies globally authorize below treatments:

0.15-0.3 mg/kg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

0.15 - 0.3 mg per kg of body weight

Dosage regimen

From 0.05 To 0.1 mg per kg of body weight 3 time(s) per day every day

Loading dose

0.15 mg per kg of body weight

Detailed description

The efficacy and safety of captopril have not been fully established. The use of captopril in children and adolescents should be initiated under close medical supervision. The initial dose of captopril is about 0.3 mg/kg body weight. For patients requiring special precautions (children with renal dysfunction, premature infants, new-borns and infants, because their renal function is not the same with older children and adults) the starting dose should be only 0.15 mg captopril/kg weight. Generally, captopril is administered to children 3 times a day, but dose and interval of dose should be adapted individually according to patient’s response.

Active ingredient

Captopril

Captopril is a highly specific, competitive inhibitor of angiotensin-I converting enzyme (ACE inhibitors). Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. In patients with hypertension, captopril causes a reduction in supine and erect blood pressure, without inducing any compensatory increase in heart rate, nor water and sodium retention.

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