Captopril

Active ingredient description

Captopril is a highly specific, competitive inhibitor of angiotensin-I converting enzyme (ACE inhibitors). Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. In patients with hypertension, captopril causes a reduction in supine and erect blood pressure, without inducing any compensatory increase in heart rate, nor water and sodium retention.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Captopril
C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain
Discover more medicines within C09AA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK

Medicines

Captopril is the active ingredient of these drugs:

Drug
Countries

Ireland

Cyprus

Tunisia

Brazil

Hong Kong

South Africa

Brazil

Tunisia

Australia New Zealand

Brazil

Brazil

Hong Kong Tunisia

Germany

Germany

Brazil

Lithuania South Africa

Brazil

Hong Kong

Brazil

Brazil

Brazil

Spain

Brazil

Singapore

Tunisia

Singapore

Cyprus Hong Kong Singapore

Brazil

Tunisia

Turkey

Tunisia

Tunisia

Turkey

France United Kingdom

Brazil

Cyprus Hong Kong

South Africa

Tunisia

Brazil

South Africa

Captopril is also found within below combination drugs:

ACTOZID , CAPTOGAMMA HCT , CAPTORETIC , CAPTOZID , CAPTRAL ASA , CO-TENSOPRIL , DILABAR DIU , ECAZIDE , SUPERACE , ZAPTO-CO

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₉H₁₅NO₃S
Molecular mass: 217.285 g/mol

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 62571-86-2
DrugBank Drug: DB01197
KEGG Drug: D00251
PubChem Compound: 44093
RxNorm Ingredient: 1998
SNOMED-CT Concept: 387160004
Captopril (substance)
UNII Identifier: 9G64RSX1XD
CAPTOPRIL