Acute pain conditions

Active Ingredient: Etoricoxib

Indication for Etoricoxib

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

60-90 mg once daily

Route of admnistration

Oral

Defined daily dose

60 - 90 mg

Dosage regimen

From 60 To 90 mg once every day

Loading dose

60 mg

Detailed description

The recommended dose is 60 mg once daily. For acute pain conditions, etoricoxib should be used only for the acute symptomatic period.

Dosage considerations

Etoricoxib is administered orally and may be taken with or without food. The onset of the effect of the medicinal product may be faster when etoricoxib is administered without food. This should be considered when rapid symptomatic relief is needed.

Active ingredient

Etoricoxib

Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose range. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified. COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function). It may also play a role in ulcer healing. COX-2 has been identified in tissue around gastric ulcers in man but its relevance to ulcer healing has not been established.

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