Etoricoxib

Chemical formula: C₁₈H₁₅ClN₂O₂S  Molecular mass: 358.842 g/mol  PubChem compound: 123619

Active ingredient description

Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose range. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified. COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function). It may also play a role in ulcer healing. COX-2 has been identified in tissue around gastric ulcers in man but its relevance to ulcer healing has not been established.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
M01AH05 Etoricoxib M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01A Antiinflammatory and antirheumatic products, non-steroids → M01AH Coxibs
Discover more medicines within M01AH05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ARCOXIA Film-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 202409-33-4
DrugBank Drug: DB01628
KEGG Drug: D03710
PubChem Compound: 123619
RxNorm Ingredient: 307296
SNOMED-CT Concept: 409134009
Etoricoxib (substance)
UNII Identifier: WRX4NFY03R
ETORICOXIB

Medicines

Etoricoxib is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Cyprus (CY)

Finland (FI)

France (FR)

Ireland (IE)

Israel (IL)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Singapore (SG)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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