Etoricoxib

Active ingredient description

Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose range. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified. COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function). It may also play a role in ulcer healing. COX-2 has been identified in tissue around gastric ulcers in man but its relevance to ulcer healing has not been established.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Etoricoxib
M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01A Antiinflammatory and antirheumatic products, non-steroids → M01AH Coxibs
Discover more medicines within M01AH05

Medicines

Etoricoxib is the active ingredient of these drugs:

Drug
Countries

Spain

Italy

Hong Kong

Austria Brazil Cyprus Estonia Finland

New Zealand

Spain

Lithuania

Estonia

Singapore

South Africa

South Africa

Poland

Estonia Lithuania

Poland

Hong Kong

South Africa

Poland

Estonia Lithuania

Germany

Germany

Germany

South Africa

Estonia Hong Kong

Hong Kong

Hong Kong

Italy Singapore South Africa

South Africa

Spain

Hong Kong

Brazil

Hong Kong

Poland

Hong Kong

Cyprus

South Africa

Estonia Lithuania

South Africa

Hong Kong

Poland

South Africa

Hong Kong

Italy

Hong Kong

South Africa

South Africa

Spain

Hong Kong

Poland

Italy

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

WRX4NFY03R - ETORICOXIB

CAS registry number

202409-33-4 - etoricoxib

SNOMED-CT

409134009 - Etoricoxib (substance)