Cryptococcal meningitis

Active Ingredient: Fluconazole

Indication for Fluconazole

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

200-800 mg once a day

Route of admnistration

Intravenous

Defined daily dose

200 - 800 mg

Dosage regimen

From 200 To 800 mg once every day

Loading dose

400 mg

Maintenance dose

200 mg

Detailed description

Loading dose: 400 mg on Day 1.

Subsequent dose: 200 mg to 400 mg once daily.

Duration: Usually at least 6 to 8 weeks. In life threatening infections the daily dose can be increased to 800 mg.

Maintenance therapy to prevent relapse of cryptococcal meningitis in patients with high risk of recurrence:

Dose: 200 mg once daily.

Duration: Indefinitely at a daily dose of 200 mg.

Dosage considerations

Intravenous infusion should be administrated at a rate not exceeding 10 ml/minute.

200-800 mg once a day

Route of admnistration

Oral

Defined daily dose

200 - 800 mg

Dosage regimen

From 200 To 800 mg once every day

Loading dose

400 mg

Maintenance dose

200 mg

Detailed description

Loading dose: 400 mg on Day 1.

Subsequent dose: 200 mg to 400 mg once daily.

Duration: Usually at least 6 to 8 weeks. In life threatening infections the daily dose can be increased to 800 mg.

Maintenance therapy to prevent relapse of cryptococcal meningitis in patients with high risk of recurrence:

Dose: 200 mg once daily.

Duration: Indefinitely at a daily dose of 200 mg.

Active ingredient

Fluconazole

Fluconazole is a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis.

Read more about Fluconazole

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