Epilepsy

Active Ingredient: Valproic acid

Indication for Valproic acid

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of generalised, partial or other epilepsy.

For this indication, competent medicine agencies globally authorize below treatments:

20-40 mg/kg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

20 - 40 mg per kg of body weight

Dosage regimen

From 6.667 To 13.333 mg per kg of body weight 3 time(s) per day every day

Detailed description

Children over 20 kg: Initial dosage should be 400 mg/day (irrespective of weight) with spaced increases until control is achieved; this is usually within the range 20–30 mg/kg body weight per day (to the nearest whole 50 mg sachet. Where adequate control is not achieved within this range the dose may be increased to 35 mg/kg body weight per day. Above 40 mg/kg/day, clinical chemistry and haematological parameters should be monitored.

Children under 20 kg: 20 mg/kg of body weight per day (to the nearest whole 50 mg sachet); in severe cases this may be increased but only in patients in whom plasma valproic acid levels can be monitored. Above 40 mg/kg/day, clinical chemistry and haemotological parameters should be monitored.

20-40 mg/kg in 3 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

20 - 40 mg per kg of body weight

Dosage regimen

From 6.667 To 13.333 mg per kg of body weight 3 time(s) per day every day

Detailed description

Use with children: Daily requirement for children is usually in the range 20–30 mg/kg/day and method of administration is as above. Where adequate control is not achieved within this range the dose may be increased up to 40 mg/kg/day but only in patients in whom plasma valproic acid levels can be monitored. Above 40 mg/kg/day clinical chemistry and haematological parameters should be monitored.

Active ingredient

Valproic acid

Valproic acid is anti-convulsant. The most likely mode of action for valproate is potentiation of the inhibitory action of gamma amino butyric acid (GABA) through an action on the further synthesis or further metabolism of GABA.

Read more about Valproic acid

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