Active Ingredient: Milrinone
Milrinone is indicated for the short-term treatment of severe congestive heart failure unresponsive to conventional maintenance therapy, and for the treatment of patients with acute heart failure, including low output states following cardiac surgery.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
50 - 75 ug per kg of body weight
From 50 To 75 ug per kg of body weight once every day
50 ug per kg of body weight
In published studies selected doses for infants and children were:
In clinical studies on low cardiac output syndrome in infants and children under 6 years of age after corrective surgery for congenital heart disease 75 μg/kg loading dose over 60 minutes followed by a 0.75 μg/kg/min infusion for 35 hours significantly reduced the risk of development of low cardiac output syndrome.
Results of pharmacokinetic studies have to be taken into consideration.
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