Active Ingredient: Capecitabine
Capecitabine is indicated for the treatment of first-line treatment of advanced gastric cancer in combination with a platinum based regimen.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A
Oral, between 800 milligrams capecitabine per square meter of body surface and 1,000 milligrams capecitabine per square meter of body surface, 2 times daily to meals, 28 doses in total, over the duration of 21 days.
Regimen B
Oral, 625 milligrams capecitabine per square meter of body surface, 2 times daily to meals, over the duration of 21 days.
In combination treatment, the recommended starting dose of capecitabine should be reduced to 800-1000 mg/m² when administered twice daily for 14 days followed by a 7-day rest period, or to 625 mg/m² twice daily when administered continuously. For combination with irinotecan, the recommended starting dose is 800 mg/m² when administered twice daily for 14 days followed by a 7-day rest period combined with irinotecan 200 mg/m² on day 1. The inclusion of bevacizumab in a combination regimen has no effect on the starting dose of capecitabine. Premedication to maintain adequate hydration and anti-emesis according to the cisplatin summary of product characteristics should be started prior to cisplatin administration for patients receiving the capecitabine plus cisplatin combination. Premedication with antiemetics according to the oxaliplatin summary of product characteristics is recommended for patients receiving the capecitabine plus oxaliplatin combination.
It should be taken with water within 30 minutes after a meal.
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