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Capecitabine

Description

Capecitabine is a non-cytotoxic fluoropyrimidine carbamate, which functions as an orally administered precursor of the cytotoxic moiety 5-fluorouracil (5-FU). There is evidence that the metabolism of 5-FU in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid, thereby interfering with the synthesis of deoxyribonucleic acid (DNA). The incorporation of 5-FU also leads to inhibition of RNA and protein synthesis.

ATC Classification

Code
Title
Category
L01BC06
Capecitabine
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues

Trade names

Trade name
Countries

Austria

Singapore

Austria

Singapore

Cyprus Singapore

Australia

Austria Canada Cyprus Netherlands Singapore

Product Monographs

Monograph
Type
Country
CAPECITABINE ACCORD Film-coated tablets
MPI, EU: SmPC