Active Ingredient: Acitretin
Acitretin is indicated for:
For this indication, competent medicine agencies globally authorize below treatments:
Oral
25 - 75 mg
From 25 To 75 mg once every day
25 mg
50 mg
Initial daily dose should be 25mg or 30mg for 2 to 4 weeks. After this initial treatment period the involved areas of the skin should show a marked response and/or side-effects should be apparent. Following assessment of the initial treatment period, titration of the dose upwards or downwards may be necessary to achieve the desired therapeutic response with the minimum of side-effects. In general, a daily dosage of 25-50mg taken for a further 6 to 8 weeks achieves optimal therapeutic results. However, it may be necessary in some cases to increase the dose up to a maximum of 75mg/day.
In patients with Darier’s disease a starting dose of 10mg may be appropriate. The dose should be increased cautiously as isomorphic reactions may occur.
Therapy can be discontinued in patients with psoriasis whose lesions have improved sufficiently. Relapses should be treated as described above.
Patients with severe congenital ichthyosis and severe Darier’s disease may require therapy beyond 3 months. The lowest effective dosage, not exceeding 50mg/day, should be given.
Continuous use beyond 6 months is contra-indicated as only limited clinical data are available on patients treated beyond this length of time.
Should be taken once daily with meals or with milk.
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