Active Ingredient: Ketorolac
Ketorolac is indicated for the short-term management of moderate to severe acute post-operative pain.
Ketorolac should only be initiated in hospitals. The maximum duration of treatment is two days.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intramuscular, 10 milligrams ketorolac, one dose. Afterwards, intramuscular, between 10 milligrams ketorolac and 30 milligrams ketorolac, once every 4 to 6 hours, over the duration of up to 2 days.
The recommended initial dose of ketorolac is 10 mg, followed by 10 to 30 mg every four to six hours as required. In the initial post-operative period, ketorolac may be given as often as every two hours if needed. The lowest effective dose should be given. A total daily dose of 90 mg for non-elderly and 60 mg for the elderly, renally-impaired patients and patients less than 50 kg should not be exceeded. The maximum duration of treatment should not exceed two days.
Reduce dosage in patients under 50 kg.
Opioid analgesics (e.g. morphine, pethidine) may be used concomitantly, and may be required for optimal analgesic effect in the early post-operative period when pain is most severe. Ketorolac does not interfere with opioid binding and does not exacerbate opioid-related respiratory depression or sedation. When used in association with ketorolac IM/IV, the daily dose of opioid is usually less than that normally required. However, opioid side-effects should still be considered, especially in day-case surgery.
The elderly are at increased risk of the serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest effective dose should be used and for the shortest possible duration. The patient should be monitored regularly for GI bleeding during NSAID therapy. A total daily dose of 60 mg should not be exceeded.
For:
Intravenous, 10 milligrams ketorolac, one dose. Afterwards, intravenous, between 10 milligrams ketorolac and 30 milligrams ketorolac, once every 4 to 6 hours, over the duration of up to 2 days.
The recommended initial dose of ketorolac is 10 mg, followed by 10 to 30 mg every four to six hours as required. In the initial post-operative period, ketorolac may be given as often as every two hours if needed. The lowest effective dose should be given. A total daily dose of 90 mg for non-elderly and 60 mg for the elderly, renally-impaired patients and patients less than 50 kg should not be exceeded. The maximum duration of treatment should not exceed two days.
Reduce dosage in patients under 50 kg.
Opioid analgesics (e.g. morphine, pethidine) may be used concomitantly, and may be required for optimal analgesic effect in the early post-operative period when pain is most severe. Ketorolac does not interfere with opioid binding and does not exacerbate opioid-related respiratory depression or sedation. When used in association with ketorolac IM/IV, the daily dose of opioid is usually less than that normally required. However, opioid side-effects should still be considered, especially in day-case surgery.
The elderly are at increased risk of the serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest effective dose should be used and for the shortest possible duration. The patient should be monitored regularly for GI bleeding during NSAID therapy. A total daily dose of 60 mg should not be exceeded.
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