Active Ingredient: Fluoxetine
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 20 milligrams fluoxetine, once daily, over the duration of 3 to 4 weeks. Afterwards, oral, between 20 milligrams fluoxetine and 60 milligrams fluoxetine, once daily, over the duration of 6 months. The maximum allowed total dose is 60 milligrams fluoxetine daily.
The recommended dose is 20mg daily. Dosage should be reviewed and adjusted if necessary, within 3 to 4 weeks of initiation of therapy and thereafter as judged clinically appropriate. Although there may be an increased potential for undesirable effects at higher doses, in some patients, with insufficient response to 20mg, the dose may be increased gradually up to a maximum of 60mg. Dosage adjustments should be made carefully on an individual patient basis, to maintain the patients at the lowest effective dose.
Patients with depression should be treated for a sufficient period of at least 6 months to ensure that they are free from symptoms.
Caution is recommended when increasing the dose, and the daily dose should generally not exceed 40mg. Maximum recommended dose is 60mg/day.
Abrupt discontinuation should be avoided. When stopping treatment with fluoxetine the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose, but at a more gradual rate.
Fluoxetine may be administered as a single or divided dose, during or between meals.
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