For this indication, competent medicine agencies globally authorize below treatments:
Oral
120 - 130 mg per m² of body surface area (BSA)
From 120 To 130 mg per m² of body surface area (BSA) once every 42 day(s) for 1 day(s)
Lomustine is given by mouth. The recommended dose in patients with normally functioning bone marrow receiving lomustine as their only chemotherapy is 120–130 mg/m² as a single dose every six to eight weeks (or as a divided dose over 3 days, e.g. 40 mg/m²/day).
Dosage is reduced:
Marrow depression after lomustine is sustained longer than after nitrogen mustards and recovery of white cell and platelet counts may not occur for six weeks or more. Blood elements depressed below the above levels should be allowed to recover to 4,000/mm³ (WBC) and 100,000/mm³ (platelets) before repeating lomustine dosage.
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