Lomustine Other names: CCNU Chloroethylcyclohexylnitrosourea

Chemical formula: C₉H₁₆ClN₃O₂  Molecular mass: 233.695 g/mol  PubChem compound: 3950

Active ingredient description

Lomustine’s mode of action is believed to be partly as an alkylating agent and partly by inhibition of several steps in the synthesis of nucleic acid and inhibition of the repair of single strand breaks in DNA chains.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01AD02 Lomustine L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AD Nitrosoureas
Discover more medicines within L01AD02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LOMUSTINE MEDAC Capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 13010-47-4
DrugBank Drug: DB01206
KEGG Drug: D00363
PubChem Compound: 3950
RxNorm Ingredient: 6466
SNOMED-CT Concept: 387227009
Lomustine (substance)
UNII Identifier: 7BRF0Z81KG
LOMUSTINE

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.