Active Ingredient: Artesunate
Artesunate is indicated for the initial treatment of severe malaria in adults and children.
Consideration should be given to official guidance on the appropriate use of antimalarial agents.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 2.4 milligrams artesunate per kilogram of body weight, once every 12 hours, 3 doses in total.
Initial treatment of severe malaria with artesunate should always be followed by a complete treatment course with appropriate oral antimalarial therapy.
The recommended dose is 2.4 mg/kg (0.24 mL of reconstituted solution for injection per kg body weight) by intravenous (IV) injection at 0, 12 and 24 hours.
After at least 24 hours (3 doses) treatment with artesunate, patients unable to tolerate oral treatment may continue to receive intravenous treatment with 2.4 mg/kg once every 24 hours (from 48 hours after start of treatment).
Treatment with artesunate should be stopped when patients can tolerate oral treatment. After stopping artesunate, all patients should receive a complete treatment course of an appropriate oral combination antimalarial regimen.
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