Artesunate

Chemical formula: C₁₉H₂₈O₈  Molecular mass: 384.425 g/mol  PubChem compound: 6917864

Active ingredient description

Artesunate is a semi-synthetic artemisinin derivative, indicated for the initial treatment of severe malaria in adults and children. The antimalarial mechanism of action of artesunate is generally thought to depend upon activation involving iron-mediated cleavage of the endoperoxide bridge of DHA to generate an unstable organic free radical followed by alkylation, where the free radical binds to malarial proteins leading to destruction of parasite membranes.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
P01BE03 Artesunate P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01B Antimalarials → P01BE Artemisinin and derivatives
Discover more medicines within P01BE03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 ARTESUNATE AMIVAS Powder and solvent for solution for injection MPI, EU: SmPC European Medicines Agency (EU)
 ARTESUNATE Powder for solution for injection MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 182824-33-5
CAS Substance: 88495-63-0
DrugBank Drug: DB09274
KEGG Drug: D02482
PubChem Compound: 6917864
RxNorm Ingredient: 18346
SNOMED-CT Concept: 432410005
Artesunate (substance)
UNII Identifier: 60W3249T9M
ARTESUNATE

Medicines

Artesunate is an active ingredient of these brands:

Netherlands (NL)

Nigeria (NG)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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