Chemical formula: C₁₉H₂₈O₈ Molecular mass: 384.425 g/mol PubChem compound: 6917864
Artesunate is a semi-synthetic artemisinin derivative, indicated for the initial treatment of severe malaria in adults and children. The antimalarial mechanism of action of artesunate is generally thought to depend upon activation involving iron-mediated cleavage of the endoperoxide bridge of DHA to generate an unstable organic free radical followed by alkylation, where the free radical binds to malarial proteins leading to destruction of parasite membranes.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| P01BE03 | Artesunate | P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01B Antimalarials → P01BE Artemisinin and derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ARTESUNATE Powder for solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| ARTESUNATE AMIVAS Powder and solvent for solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC |
Artesunate is an active ingredient of these brands:
Netherlands (NL)Nigeria (NG)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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