Essential thrombocythaemia

Active Ingredient: Busulfan

Indication for Busulfan

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

2-4 mg/kg in 2-4 divided doses daily

Route of admnistration

Oral

Defined daily dose

2 - 4 mg per kg of body weight

Dosage regimen

From 0.5 To 1 mg per kg of body weight 4 time(s) per day every day

Detailed description

The usual dose is 2 to 4 mg per day.

Treatment should be interrupted if the total leucocyte count falls below 5 × 109 per litre or the platelet count below 500 × 109 per litre.

Active ingredient

Busulfan

Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect.

Read more about Busulfan

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