Chemical formula: C₆H₁₄O₆S₂ Molecular mass: 246.302 g/mol PubChem compound: 2478
Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01AB01 | Busulfan | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AB Alkyl sulfonates |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| MYLERAN Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| BUSULFEX Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| BUSILVEX Concentrate for solution | European Medicines Agency (EU) | MPI, EU: SmPC | |
| BUSULFAN Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Busulfan is an active ingredient of these brands:
Australia (AU)Brazil (BR)Canada (CA)Finland (FI)Mexico (MX)New Zealand (NZ)Romania (RO)Spain (ES)Tunisia (TN)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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