Active Ingredient: Dacarbazine
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
200 - 250 mg per m² of body surface area (BSA)
From 200 To 250 mg per m² of body surface area (BSA) once every day for 5 day(s)
Dacarbazine can be administered as single agent in doses of 200 to 250 mg/m² body surface area/day as an i.v. injection for 5 days every 3 weeks.
As an alternative to an intravenous bolus injection dacarbazine can be administered as a short-term infusion (over 15-30 minutes).
Doses up to 200 mg/m² may be given as a slow intravenous injection. Larger doses (ranging from 200 to 850 mg/m²) should be administered as an i.v. infusion over 15-30 minutes.
Intravenous
850 - 850 mg per m² of body surface area (BSA)
From 850 To 850 mg per m² of body surface area (BSA) once every 21 day(s)
It is also possible to give 850 mg/m² body surface area on day 1 and then once every 3 weeks as intravenous infusion.
Doses up to 200 mg/m² may be given as a slow intravenous injection. Larger doses (ranging from 200 to 850 mg/m²) should be administered as an i.v. infusion over 15-30 minutes.
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