Hypercholesterolaemia Fredrickson's Type II

Active Ingredient: Colestyramine

Indication for Colestyramine

Population group: only adults (18 years old or older)

Reduction of plasma cholesterol in hypercholesterolaemia, particularly in those patients who have been diagnosed as Fredrickson’s Type II (high plasma cholesterol with normal or slightly elevated triglycerides).

For this indication, competent medicine agencies globally authorize below treatments:

4-36 g in 1-4 divided doses daily

Route of admnistration


Defined daily dose

4 - 36 g

Dosage regimen

From 2 To 18 g 2 time(s) per day every day

Detailed description

After initial introduction over a three to four week period, 12 to 24 g per day, administered either as a single daily dose or in divided doses up to four times daily, according to dosage requirements and patient acceptability. Dosage may be modified according to response and can be increased to 36 g per day if necessary.

Occasional slight gastrointestinal upsets, e.g. constipation, may occur when starting Questran Light. These usually pass with continued usage of Questran Light and are minimised by starting therapy gradually.

Final dose requiredWeek 1Week 2Week 3Week 4
 g per day

Dosage considerations

As a precautionary measure, where concurrent drug therapy exists then such drugs should be administered at least one hour before or 4-6 hours after colestyramine.

Colestyramine should not be taken in its dry form.

Colestyramine should be administered mixed with water or a suitable liquid, such as fruit juice, and stirred to a uniform consistency.

Colestyramine may also be mixed with skimmed milk, thin soups, pulpy fruits with high moisture content, e.g. apple sauce, etc.

Active ingredient


Colestyramine resin absorbs and combines with the bile acids in the intestine to form an insoluble complex which is excreted in the faeces. This results in an increased faecal loss of bile acids which leads to an increased oxidation of cholesterol to bile acids and a decrease in serum cholesterol levels and low density lipoprotein serum levels.

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