Visceral leishmaniasis

Active Ingredient: Amphotericin B

Indication for Amphotericin B

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Amphotericin B is indicated for the treatment of visceral leishmaniasis in immunocompetent patients including both adults and children.

For this indication, competent medicine agencies globally authorize below treatments:

1.5-2 mg/kg once daily

Route of admnistration


Defined daily dose

1 - 1.5 mg per kg of body weight

Dosage regimen

From 1 To 1.5 mg per kg of body weight once every day for 21 day(s)

Detailed description

A total dose of 21.0-30.0 mg/kg of body weight given over 10-21 days may be used in the treatment of visceral leishmaniasis. Particulars as to the optimal dosage and the eventual development of resistance are as yet incomplete. The product should be administered under strict medical supervision.

Dosage considerations

Amphotericin B should be administered by intravenous infusion over a 30-60 minute period. For doses greater than 5mg/kg/day, intravenous infusion over a 2 hour period is recommended.

Active ingredient

Amphotericin B

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Read more about Amphotericin B

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