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Amphotericin B

Description

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

ATC Classification

Code
Title
Category
A01AB04
Amphotericin B
A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
A07AA07
Amphotericin B
A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
G01AA03
Amphotericin B
G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
J02AA01
Amphotericin B
J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AA Antibiotics

Trade names

Trade name
Countries
ABELCET

Canada France Netherlands United States

AMBISOME

Austria Canada Cyprus France Netherlands

AMPHO-MORONAL

Austria

FUNGILIN

Australia

FUNGIZONE

Canada France Netherlands

Product Monographs

Monograph
Type
Country
AMBISOME Powder for solution for infusion
MPI, EU: SmPC
UK

2D Molecule Structure

Unique Ingredient Identifier (UNII)

7XU7A7DROE - AMPHOTERICIN B

CAS Registry Number

1397-89-3 - amphotericin B

SNOMED-CT

77703004 - Amphotericin B (substance)

 
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