Amphotericin B

Active ingredient description

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A01AB04
Amphotericin B
A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
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A07AA07
Amphotericin B
A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
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G01AA03
Amphotericin B
G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
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J02AA01
Amphotericin B
J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AA Antibiotics
Discover more medicines within J02AA01

Medicines

Amphotericin B is the active ingredient of these drugs:

Drug
Countries
ABELCET

Brazil Canada France Netherlands Poland

AMBISOME

Austria Brazil Canada Cyprus Finland

AMFOCARE

Lithuania

AMPHO-MORONAL

Austria Lithuania

FUNGILIN

Australia New Zealand

FUNGIZONE

Canada Finland France Hong Kong Ireland

UNIANF

Brazil

Amphotericin B is also found within below combination drugs:

FUNGITRIN , NOVASUTIN , TERICIN AT

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
AMBISOME Powder for solution for infusion
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

7XU7A7DROE - AMPHOTERICIN B

CAS registry number

1397-89-3 - amphotericin B

SNOMED-CT

77703004 - Amphotericin B (substance)

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