Amphotericin B

Active ingredient description

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A01AB04
Amphotericin B
A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
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A07AA07
Amphotericin B
A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
Discover more medicines within A07AA07
G01AA03
Amphotericin B
G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
Discover more medicines within G01AA03
J02AA01
Amphotericin B
J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AA Antibiotics
Discover more medicines within J02AA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
AMBISOME Powder for solution for infusion
Summary of Product Characteristics (SPC)
UK

Medicines

Amphotericin B is the active ingredient of these drugs:

Drug
Countries
ABELCET

Brazil Canada France Mexico Netherlands

ABHOPE

Estonia

AMBILON

Estonia

AMBISOME

Austria Brazil Canada Cyprus Estonia

AMFIGHT

Estonia

AMFOCARE

Lithuania

AMPHO-MORONAL

Austria Estonia Lithuania

AMPHOLIP

Ecuador

AMPHONEX

Ecuador Estonia

BDSOMAL-B

Estonia

FUNGILIN

Australia New Zealand

FUNGIPLUS

Ecuador

FUNGIZONE

Canada Estonia Finland France Hong Kong

GUFISOME

Estonia

PHOTERICIN-B

Ecuador

UNIANF

Brazil

Amphotericin B is also found within below combination drugs:

FUNGITRIN , NOVASUTIN , TERICIN AT

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₄₇H₇₃NO₁₇
Molecular mass: 924.079 g/mol

External identifiers

CAS Substance: 1397-89-3
DrugBank Drug: DB00681
KEGG Drug: D00203
PubChem Compound: 5280965
RxNorm Ingredient: 732
SNOMED-CT Concept: 77703004
Amphotericin B (substance)
UNII Identifier: 7XU7A7DROE
AMPHOTERICIN B
 
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