Amphotericin B

Active ingredient description

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Amphotericin B
A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
Discover more medicines within A01AB04
Amphotericin B
A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
Discover more medicines within A07AA07
Amphotericin B
G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
Discover more medicines within G01AA03
Amphotericin B
J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AA Antibiotics
Discover more medicines within J02AA01

Medicines

Amphotericin B is the active ingredient of these drugs:

Drug
Countries

Brazil Canada France Netherlands Poland

Estonia

Estonia

Austria Brazil Canada Cyprus Estonia

Estonia

Lithuania

Austria Estonia Lithuania

Ecuador

Ecuador Estonia

Estonia

Australia New Zealand

Ecuador

Canada Estonia Finland France Hong Kong

Estonia

Ecuador

Brazil

Amphotericin B is also found within below combination drugs:

FUNGITRIN , NOVASUTIN , TERICIN AT

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

7XU7A7DROE - AMPHOTERICIN B

CAS registry number

1397-89-3 - amphotericin B

SNOMED-CT

77703004 - Amphotericin B (substance)