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ATC Group: A07AA Antibiotics

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A07
Antidiarrheals, intestinal antiinflammatory/antiinfective agents
3
A07A
Intestinal antiinfectives
4
A07AA
Antibiotics

Contents

Code
Title
A07AA01
Neomycin
A07AA02
Nystatin
A07AA03
Natamycin
A07AA04
Streptomycin
A07AA05
Polymyxin B
A07AA06
Paromomycin
A07AA07
Amphotericin B
A07AA08
Kanamycin
A07AA09
Vancomycin
A07AA10
Colistin
A07AA11
Rifaximin
A07AA12
Fidaxomicin
A07AA13
Rifamycin
A07AA51
Neomycin, combinations
A07AA54
Streptomycin, combinations

Active Ingredients

Chemical substance
Description
Amphotericin B

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Colistimethate sodium

Colistimethate sodium (CMS) is a cyclic polypeptide antibacterial active substance that is derived from Bacillus polymyxa var colistinus and belongs to the polymyxin group. Polymyxins work by damaging the cell membrane and the resulting physiological effects are lethal to the bacterium. Polymyxins are selective for Gram-negative bacteria that have a hydrophobic outer membrane.

Colistin

Colistin is a cyclic polypeptide antibacterial agent belonging to the polymyxin group. Polymyxins work by damaging the cell membrane and the resulting physiological effects are lethal to the bacterium. Polymyxins are selective for aerobic Gram-negative bacteria that have a hydrophobic outer membrane.

Fidaxomicin

Fidaxomicin is an antibiotic belonging to the macrocyclic class of antibacterials. Fidaxomicin is bactericidal and inhibits RNA synthesis by bacterial RNA polymerase. It interferes with RNA polymerase at a distinct site from that of rifamycins. Fidaxomicin is indicated for the treatment of Clostridioides difficile infections (CDI) also known as C. difficile-associated diarrhoea (CDAD) in adult and paediatric patients.

Natamycin

Natamycin is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. The mechanism of action appears to be through binding of the molecule to the sterol moiety of the fungal cell membrane.

Neomycin

Neomycin is an aminoglycoside antibiotic and acts by binding to polysomes, inhibiting protein synthesis and generating errors in the transcription of the genetic code.

Nystatin

Nystatin is an antifungal antibiotic active against a wide range of yeasts and yeast-like fungi, including Candida albicans.

Polymyxin B

Polymixin B is bactericidal against a wide range of gram negative bacilli. It exerts a bactericidal effect by binding to acid phospholipids in the cell wall and membranes of the bacterium, thereby rendering ineffective the osmotic barrier normally provided by the cell membrane.

Rifaximin

Rifaximin is an antibacterial agent of the rifamycin class that inhibits bacterial RNA synthesis. Rifaximin has a broad antimicrobial spectrum against most of the Gram-positive and -negative, aerobic and anaerobic bacteria responsible for intestinal infections.

Streptomycin

Streptomycin is a broad spectrum aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin is typically used for treatment of active tuberculosis, always in combination with other antituberculosis agents.

Vancomycin

Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units.

Monographs

Monograph
Type
Country
DIFICID Film-coated tablet
MPI, US: SPL/PLR
US
DIFLICIR Film-coated tablet
MPI, EU: SmPC
NIVEMYCIN Tablets
MPI, EU: SmPC
UK
VANCOCIN Capsule
MPI, US: SPL/PLR
US
VANCOMYCIN Powder for solution for intravenous infusion / oral use
MPI, EU: SmPC
UK
XIFAXAN Tablet
MPI, US: SPL/PLR
US