Natamycin Other names: Pimaricin

Chemical formula: C₃₃H₄₇NO₁₃  Molecular mass: 665.733 g/mol  PubChem compound: 5284447

Active ingredient description

Natamycin is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. The mechanism of action appears to be through binding of the molecule to the sterol moiety of the fungal cell membrane.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AB10 Natamycin A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
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A07AA03 Natamycin A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
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D01AA02 Natamycin D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AA Antibiotics
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G01AA02 Natamycin G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
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S01AA10 Natamycin S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
NATACYN Ophthalmic suspension, drops FDA, National Drug Code (US) MPI, US: SPL/Old

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 7681-93-8
DrugBank Drug: DB00826
KEGG Drug: D00884
PubChem Compound: 5284447
RxNorm Ingredient: 7268
SNOMED-CT Concept: 372712006
Natamycin (substance)
UNII Identifier: 8O0C852CPO
NATAMYCIN

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