Colistimethate Other names: Colistimethate sodium

Chemical formula: C₅₉H₁₁₄N₁₆O₃₀S₆  Molecular mass: 1,634.87 g/mol  PubChem compound: 70789202

Active ingredient description

Colistimethate is a cyclic polypeptide antibacterial active substance that is derived from Bacillus polymyxa var colistinus and belongs to the polymyxin group. Polymyxins work by damaging the cell membrane and the resulting physiological effects are lethal to the bacterium. Polymyxins are selective for Gram-negative bacteria that have a hydrophobic outer membrane.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A07AA10 Colistin A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics
Discover more medicines within A07AA10
J01XB01 Colistin J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01X Other antibacterials → J01XB Polymyxins
Discover more medicines within J01XB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
COLOBREATHE Inhalation powder, hard capsule European Medicines Agency (EU) MPI, EU: SmPC
COLISTIMETHATE SODIUM 1 Million I.U. Powder for solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

External identifiers

CAS Substance: 2680-63-9
CAS Substance: 30387-39-4
CAS Substance: 8068-28-8
DrugBank Drug: DB01111
KEGG Drug: D02049
PubChem Compound: 70789202
RxNorm Ingredient: 2708
SNOMED-CT Concept: 82885001
Colistimethate (substance)
UNII Identifier: DL2R53P963


Colistimethate is an active ingredient of these brands:

United States (US)

Austria (AT)

Brazil (BR)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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