Active Ingredient: Lansoprazole
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 30 milligrams lansoprazole, 2 times daily -30 minutes before meals, over the duration of 7 to 14 days.
When selecting appropriate combination therapy consideration should be given to official local guidance regarding bacterial resistance, duration of treatment, (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents.
The recommended dose is 30 mg of Lansoprazole twice daily for 7 days in combination with one of the following:
H. pylori eradication rates of up to 90%, are obtained when clarithromycin is combined with lansoprazole and amoxicillin or metronidazole.
Six months after successful eradication treatment, the risk of re-infection is low and relapse is therefore unlikely.
Use of a regimen including lansoprazole 30 mg twice daily, amoxicillin 1 g twice daily and metronidazole 400−500 mg twice daily has also been examined. Lower eradication rates were seen using this combination than in regimens involving clarithromycin. It may be suitable for those who are unable to take clarithromycin as part of an eradication therapy, when local resistance rates to metronidazole are low.
Due to reduced clearance of lansoprazole in older people an adjustment of dose may be necessary based on individual requirements. A daily dose of 30 mg should not be exceeded in older people unless there are compelling clinical indications.
Lansoprazole should be taken at least 30 minutes before food.
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