Cardiovascular event

Active Ingredient: Atorvastatin

Indication for Atorvastatin

Population group: only adults (18 years old or older)
Therapeutic intent: Preventive action

Prevention of cardiovascular events in adult patients estimated to have a high risk for a first cardiovascular event, as an adjunct to correction of other risk factors.

To reduce the risk of:

  • Myocardial infarction (MI), stroke, revascularization procedures, and angina in adults with multiple risk factors for coronary heart disease (CHD) but without clinically evident CHD.
  • MI and stroke in adults with type 2 diabetes mellitus with multiple risk factors for CHD but without clinically evident CHD.
  • Non-fatal MI, fatal and non-fatal stroke, revascularization procedures, hospitalization for congestive heart failure, and angina in adults with clinically evident CHD.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily for at least 4 weeks and thefeafter 10-80 mg once daily


Dosage regimens

Oral, 10 milligrams atorvastatin, once daily, over the duration of 4 weeks. Afterwards, oral, between 10 milligrams atorvastatin and 80 milligrams atorvastatin, once daily. The maximum allowed total dose is 80 milligrams atorvastatin daily.

Detailed description

The patient should be placed on a standard cholesterol-lowering diet before receiving atorvastatin and should continue on this diet during treatment with atorvastatin.

The dose should be individualised according to baseline LDL-C levels, the goal of therapy, and patient response.

The usual starting dose is 10 mg once a day. Adjustment of dose should be made at intervals of 4 weeks or more. The maximum dose is 80 mg once a day.

In the primary prevention trials the dose was 10 mg/day. Higher doses may be necessary in order to attain (LDL-) cholesterol levels according to current guidelines.

Dosage considerations

Each daily dose of atorvastatin is given all at once and may be given at any time of day with or without food.

Active ingredient


Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase. Atorvastatin lowers plasma cholesterol and lipoprotein serum concentrations by inhibiting HMG-CoA reductase and subsequently cholesterol biosynthesis in the liver and increases the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL.

Read more about Atorvastatin

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