Zollinger-Ellison syndrome

Active Ingredient: Cimetidine

Indication for Cimetidine

Population group: only adults (18 years old or older)

Cimetidine is recommended in the management of the Zollinger-Ellison syndrome.

For this indication, competent medicine agencies globally authorize below treatments:

1,600 mg in 4 divided doses daily

Route of admnistration


Defined daily dose

1,600 - 1,600 mg

Dosage regimen

From 400 To 400 mg 4 time(s) per day every day

Detailed description

In patients with very high gastric acid secretion (e.g. Zollinger-Ellison syndrome) it may be necessary to increase the dose to 400mg four times a day or in occasional cases further. Since Cimetidine may not give immediate symptomatic relief, antacids can be made available to all patients until symptoms disappear.

Active ingredient


Cimetidine is a histamine H2-receptor antagonist which rapidly inhibits both basal and stimulated gastric secretion of acid and reduces pepsin output. It is a reversible, competitive antagonist, and is used as an anti-ulcer drug.

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