Mild to moderate pneumocystis pneumonia caused by Pneumocystis jiroveci

Active Ingredient: Atovaquone

Indication for Atovaquone

Population group: only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

Atovaquone is indicated for acute treatment of mild to moderate Pneumocystis pneumonia (PCP, caused by Pneumocystis jiroveci, formerly classified as P. carinii) (alveolar – arterial oxygen tension difference [(A-a) DO2] ≤45 mmHg (6 kPa) and oxygen tension in arterial blood (PaO2) ≥60 mmHg (8 kPa) breathing room air) in patients who are intolerant of co-trimoxazole therapy.

For this indication, competent medicine agencies globally authorize below treatments:

750 mg twice daily for 21 days

For:

Dosage regimens

Oral, 750 milligrams atovaquone, 2 times daily to meals, over the duration of 21 days.

Detailed description

The recommended oral dose is 750 mg twice a day (morning and evening) administered with food each day for 21 days.

Higher doses may be more effective in some patients.

Active ingredient

Atovaquone

Atovaquone is a selective and potent inhibitor of the eukaryotic mitochondrial electron transport chain in a number of parasitic protozoa and the parasitic fungus P. jiroveci. The site of action appears to be the cytochrome bc1 complex (complex III).

Read more about Atovaquone

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