Atovaquone

Active ingredient description

Atovaquone is a selective and potent inhibitor of the eukaryotic mitochondrial electron transport chain in a number of parasitic protozoa and the parasitic fungus P. jiroveci. The site of action appears to be the cytochrome bc1 complex (complex III).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
P01AX06
Atovaquone
P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01A Agents against amoebiasis and other protozoal diseases → P01AX Other agents against amoebiasis and other protozoal diseases
Discover more medicines within P01AX06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
WELLVONE Oral suspension
Summary of Product Characteristics (SPC)
UK
MEPRON Oral suspension
Structured Product Labeling (SPL/PLR)
US

Medicines

Atovaquone is the active ingredient of these drugs:

Drug
Countries
MEPRON

Canada United States

WELLVONE

Australia Estonia France Netherlands South Africa

Atovaquone is also found within below combination drugs:

ATAPRO , FALCIMAR , FALCIRONE , MALANIL , MALARONE , MALATEQ , MALAWAY , MALOFF PROTECT , MOZITEC , NUMAL

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₂H₁₉ClO₃
Molecular mass: 366.837 g/mol

External identifiers

CAS Substance: 95233-18-4
DrugBank Drug: DB01117
KEGG Drug: D00236
PubChem Compound: 74989
RxNorm Ingredient: 60212
SNOMED-CT Concept: 386899002
Atovaquone (substance)
UNII Identifier: Y883P1Z2LT
ATOVAQUONE
 
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