Multidrug resistant HIV-1 infection

Active Ingredient: Fostemsavir

Indication for Fostemsavir

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Fostemsavir, in combination with other antiretrovirals, is indicated for the treatment of adults with multidrug resistant HIV-1 infection for whom it is otherwise not possible to construct a suppressive anti-viral regimen.

For this indication, competent medicine agencies globally authorize below treatments:

600 mg twice daily

For:

Dosage regimens

Oral, 600 milligrams fostemsavir, 2 times daily.

Detailed description

The recommended dose is 600 mg of fostemsavir twice daily.

Missed doses

If the patient misses a dose of fostemsavir, the patient should take the missed dose as soon as the patient remembers, unless it is almost time for the next dose. In this case, the missed dose should be skipped and the next dose should be taken according to the regular schedule. The patient should not take a double dose to make up for the forgotten dose.

Active ingredient

Fostemsavir

Fostemsavir is a prodrug without significant antiviral activity that is hydrolysed to the active moiety, temsavir, upon cleavage of a phosphonooxymethyl group in vivo. Temsavir binds directly to the gp120 subunit within the HIV-1 envelope glycoprotein gp160 and selectively inhibits the interaction between the virus and cellular CD4 receptor, thereby preventing viral entry into, and infection of, host cells.

Read more about Fostemsavir

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