Fostemsavir

Chemical formula: C₂₅H₂₆N₇O₈P  Molecular mass: 583.498 g/mol  PubChem compound: 11319217

Active ingredient description

Fostemsavir is a prodrug without significant antiviral activity that is hydrolysed to the active moiety, temsavir, upon cleavage of a phosphonooxymethyl group in vivo. Temsavir binds directly to the gp120 subunit within the HIV-1 envelope glycoprotein gp160 and selectively inhibits the interaction between the virus and cellular CD4 receptor, thereby preventing viral entry into, and infection of, host cells.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
J05AX29 J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AX Other antivirals
Discover more medicines within J05AX29

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 RUKOBIA Prolonged-release tablet MPI, EU: SmPC European Medicines Agency (EU)
 RUKOBIA Extended-release tablet MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 864953-29-7
DrugBank Drug: DB11796
PubChem Compound: 11319217
RxNorm Ingredient: 2380373
UNII Identifier: 97IQ273H4L
FOSTEMSAVIR

Medicines

Fostemsavir is an active ingredient of these brands:

Austria (AT)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Croatia (HR)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Estonia (EE)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Finland (FI)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

France (FR)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Ireland (IE)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Italy (IT)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Lithuania (LT)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Poland (PL)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Romania (RO)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Spain (ES)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

United States (US)

  • RUKOBIA as FOSTEMSAVIR TROMETHAMINE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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