Central nervous system lymphoma

Indication for Thiotepa

Population group: Suitable for both men and women, only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

185 mg/m² once a day

Route of admnistration

Intravenous

Defined daily dose

185 - 185 mg per m² of body surface area (BSA)

Dosage regimen

From 185 To 185 mg per m² of body surface area (BSA) once every day

Detailed description

The recommended dose is 185 mg/m²/day (5 mg/kg/day) as a single daily infusion, administered for 2 consecutive days before autologous HPCT, without exceeding the total maximum cumulative dose of 370 mg/m² (10 mg/kg), during the time of the entire conditioning treatment.

Dosage considerations

Thiotepa must be administered by a qualified healthcare professional as a 2-4 hours intravenous infusion via a central venous catheter.

5 mg/kg once a day

Route of admnistration

Intravenous

Defined daily dose

5 - 5 mg per kg of body weight

Dosage regimen

From 5 To 5 mg per kg of body weight once every day

Detailed description

The recommended dose is 185 mg/m²/day (5 mg/kg/day) as a single daily infusion, administered for 2 consecutive days before autologous HPCT, without exceeding the total maximum cumulative dose of 370 mg/m² (10 mg/kg), during the time of the entire conditioning treatment.

Dosage considerations

Thiotepa must be administered by a qualified healthcare professional as a 2-4 hours intravenous infusion via a central venous catheter.

Active ingredient

Thiotepa is a polyfunctional cytotoxic agent related chemically and pharmacologically to the nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release of ethylene imine radicals that, as in the case of irradiation therapy, disrupt the bonds of DNA, e.g. by alkylation of guanine at the N-7, breaking the linkage between the purine base and the sugar and liberating alkylated guanine.

Read more about Thiotepa

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