Thiotepa Other names: Triethylene Thiophosphoramide

Chemical formula: C₆H₁₂N₃PS  Molecular mass: 189.218 g/mol  PubChem compound: 5453

Active ingredient description

Thiotepa is a polyfunctional cytotoxic agent related chemically and pharmacologically to the nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release of ethylene imine radicals that, as in the case of irradiation therapy, disrupt the bonds of DNA, e.g. by alkylation of guanine at the N-7, breaking the linkage between the purine base and the sugar and liberating alkylated guanine.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01AC01 Thiotepa L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AC Ethylene imines
Discover more medicines within L01AC01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TEPADINA Powder for concentrate for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 52-24-4
DrugBank Drug: DB04572
KEGG Drug: D00583
PubChem Compound: 5453
RxNorm Ingredient: 10473
SNOMED-CT Concept: 387508004
Thiotepa (substance)
UNII Identifier: 905Z5W3GKH


Thiotepa is an active ingredient of these brands:

United States (US)

Austria (AT)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Romania (RO)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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