Active immunisation against varicella

Active Ingredient: Varicella, live attenuated

Indication for Varicella, live attenuated

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Therapeutic intent: Preventive action

The varicella vaccine (live) is indicated for active immunisation against varicella:

  • In healthy individuals from 9 to 11 months of age, under special circumstances;
  • In healthy individuals from the age of 12 months;
  • For post-exposure prophylaxis if administered to healthy, susceptible individuals exposed to varicella within 72 hours of contact;
  • In individuals at high risk of severe varicella.

The use of the vaccine should be based on official recommendations.

For this indication, competent medicine agencies globally authorize below treatments:

2 doses with an interval of 3 months

For:

Dosage regimens

Regimen A: Intramuscular, 0.5 milliliters varicella, live attenuated, every 3 months, 2 doses in total.

Regimen B: Subcutaneous, 0.5 milliliters varicella, live attenuated, every 3 months, 2 doses in total.

Detailed description

Infants from 9 to 11 months of age (inclusive) receive two doses of vaccine to ensure optimal protection against varicella. The second dose should be given after a minimum interval of 3 months.

Dosage considerations

Varicella vaccine is to be injected subcutaneously (SC) or intramuscularly (IM) in the deltoid region or in the anterolateral area of the thigh.

Varicella vaccine should be administered subcutaneously in individuals with bleeding disorders (e.g. thrombocytopenia or any coagulation disorder).

2 doses with an interval of 6 weeks

For:

Dosage regimens

Regimen A: Intramuscular, 0.5 milliliters varicella, live attenuated, every 6 weeks, 2 doses in total.

Regimen B: Subcutaneous, 0.5 milliliters varicella, live attenuated, every 6 weeks, 2 doses in total.

Detailed description

Children from the age of 12 months as well as adolescents and adults receive two doses of the vaccine to ensure optimal protection against varicella. The second dose should generally be given at least 6 weeks after the first dose. Under no circumstances should the interval between the doses be less than 4 weeks.

Individuals at high risk of severe varicella

Individuals at high risk of severe varicella may benefit from re-vaccination following the 2-dose schedule. Periodic measurement of varicella antibodies after immunisation may be indicated in order to identify those who may benefit from re-immunisation. Under no circumstances should the interval between the doses be less than 4 weeks.

Dosage considerations

Varicella vaccine is to be injected subcutaneously (SC) or intramuscularly (IM) in the deltoid region or in the anterolateral area of the thigh.

The vaccine should be administered subcutaneously in individuals with bleeding disorders (e.g. thrombocytopenia or any coagulation disorder).

Active ingredient

Varicella, live attenuated

Natural infection induces a cellular and humoral immune response to the varicella-zoster virus, which can be rapidly detected following infection. IgG, IgM and IgA directed against viral proteins usually appear at the same time that a cellular immune response can be demonstrated, making the relative contribution of humoral and cellular immunity to disease progression difficult to ascertain. Vaccination has been shown to induce both humoral and cell-mediated types of immunity.

Read more about Varicella, live attenuated

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