Hypertension

Active Ingredient: Amlodipine

Indication for Amlodipine

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

5 mg once daily and thereafter 5-10 mg once daily

For:

Dosage regimens

Oral, 5 milligrams amlodipine, once daily. Afterwards, oral, between 5 milligrams amlodipine and 10 milligrams amlodipine, once daily.

Detailed description

The usual initial dose is 5 mg once daily which may be increased to a maximum dose of 10 mg depending on the individual patient’s response.

In hypertensive patients, amlodipine has been used in combination with a thiazide diuretic, alpha blocker, beta blocker, or an angiotensin converting enzyme inhibitor.

No dose adjustment of amlodipine is required upon concomitant administration of thiazide diuretics, beta blockers, and angiotensin-converting enzyme inhibitors.

Elderly patients

Amlodipine used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.

2.5 mg once daily for 4 weeks and thereafter 2.5-5 mg once daily

For:

Dosage regimens

Oral, 2.5 milligrams amlodipine, once daily, over the duration of 4 weeks. Afterwards, oral, between 2.5 milligrams amlodipine and 5 milligrams amlodipine, once daily. The maximum allowed total dose is 5 milligrams amlodipine daily.

Detailed description

The recommended antihypertensive oral dose in paediatric patients ages 6-17 years is 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in paediatric patients.

Active ingredient

Amlodipine

Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.

Read more about Amlodipine

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