Breast carcinoma

Active Ingredient: Methotrexate

Indication for Methotrexate

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

40 mg/m² once on the first and eighth days of each cycle

Route of admnistration

Intravenous

Defined daily dose

40 - 40 mg per m² of body surface area (BSA)

Dosage regimen

From 40 To 40 mg per m² of body surface area (BSA) once every day

Detailed description

Prolonged cyclic combination with cyclophosphamide, methotrexate and fluorouracil has given good results when used as adjuvant treatment to radical mastectomy in primary breast cancer with positive axillary lymph nodes. Methotrexate dosage was 40 mg/m² intravenously on the first and eighth days.

Active ingredient

Methotrexate

Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases.

Read more about Methotrexate

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