Methotrexate
Also known as: 4-amino-10-methylfolic acid Amethopterin
Brand names: METOJECT OTREXUP RASUVO REDITREX TREXALL XATMEP
Description
Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases.
ATC Classification
Code
Title
Category
Methotrexate