ATC Group: L04AX03 Methotrexate

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of L04AX03 in the ATC hierarchy

Level Code Title
1 L Antineoplastic and immunomodulating agents
2 L04 Immunosuppressants
3 L04A Immunosuppressants
4 L04AX Other immunosuppressants
5 L04AX03 Methotrexate

Defined daily dose

The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. The DDD is a unit of measurement and does not necessarily reflect the recommended or Prescribed Daily Dose. Therapeutic doses for individual patients and patient groups will often differ from the DDD as they will be based on individual characteristics (such as age, weight, ethnic differences, type and severity of disease) and pharmacokinetic considerations.

Route Amount
ORAL - Oral 2.5 mg

Active ingredients in L04AX03

Active Ingredient Description
Methotrexate

Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases.

Related product monographs

Title Information Source Document Type  
METHOFILL Solution for injection in pre-filled injector Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
METHOTREXATE Solution for Injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
METHOTREXATE Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
METOJECT PEN Solution for injection in pre-filled pen Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Medicines in this ATC group

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United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.